How does paracetamol / acetaminophen relieve pain?

How does paracetamol / acetaminophen relieve pain?

Free nerve endings are responsible for the perception of pain. There are some chemical mediators of pain like bradykinin which stimulate free nerve endings and causes pain sensation. Drugs like paracetamol / acetaminophen are called NSAID s or Non Steroid Anti Inflammatory Drugs. These drugs inhibit a class of enzymes called COX ( cycloxygenase ) There are three types of cycloxygnase. COX-1, COX-2 and COX-3. COX is responsible for the synthesis of prostaglandins in various parts of the body. Prostatglandin sensitize free nerve endings to chemical mediators of pain So when the prostaglandin production decreased pain sensation decreases. Paracetamol also known to be a selective inhibitor of COX-3.